Pouliot M C, Després J P, Lemieux S, Moorjani S, Bouchard C, Tremblay A, Nadeau A, Lupien P J
Lipid Research Center, Laval University, Ste-Foy, Québec, Canada.
Am J Cardiol. 1994 Mar 1;73(7):460-8. doi: 10.1016/0002-9149(94)90676-9.
The amount of abdominal visceral adipose tissue measured by computed tomography is a critical correlate of the potentially "atherogenic" metabolic disturbances associated with abdominal obesity. In this study conducted in samples of 81 men and 70 women, data are presented on the anthropometric correlates of abdominal visceral adipose tissue accumulation and related cardiovascular disease risk factors (triglyceride and high-density lipoprotein cholesterol levels, fasting and postglucose insulin and glucose levels). Results indicate that the waist circumference and the abdominal sagittal diameter are better correlates of abdominal visceral adipose tissue accumulation than the commonly used waist-to-hip ratio (WHR). In women, the waist circumference and the abdominal sagittal diameter also appeared more closely related to the metabolic variables than the WHR. When the samples were divided into quintiles of waist circumference, WHR or abdominal sagittal diameter, it was noted that increasing values of waist circumference and abdominal sagittal diameter were more consistently associated with increases in fasting and postglucose insulin levels than increasing values of WHR, especially in women. These findings suggest that the waist circumference or the abdominal sagittal diameter, rather than the WHR, should be used as indexes of abdominal visceral adipose tissue deposition and in the assessment of cardiovascular risk. It is suggested from these data that waist circumference values above approximately 100 cm, or abdominal sagittal diameter values > 25 cm are most likely to be associated with potentially "atherogenic" metabolic disturbances.
通过计算机断层扫描测量的腹部内脏脂肪组织量,是与腹部肥胖相关的潜在“致动脉粥样硬化”代谢紊乱的关键关联因素。在这项对81名男性和70名女性样本进行的研究中,呈现了腹部内脏脂肪组织积累的人体测量学关联因素以及相关心血管疾病风险因素(甘油三酯和高密度脂蛋白胆固醇水平、空腹及葡萄糖耐量试验后的胰岛素和葡萄糖水平)的数据。结果表明,与常用的腰臀比(WHR)相比,腰围和腹部矢状径与腹部内脏脂肪组织积累的相关性更好。在女性中,腰围和腹部矢状径与代谢变量的关系似乎也比腰臀比更为密切。当将样本按腰围、腰臀比或腹部矢状径的五分位数进行划分时,发现腰围和腹部矢状径的增加比腰臀比的增加更一致地与空腹及葡萄糖耐量试验后的胰岛素水平升高相关,尤其是在女性中。这些发现表明,应使用腰围或腹部矢状径而非腰臀比作为腹部内脏脂肪组织沉积的指标以及评估心血管风险的指标。从这些数据来看,腰围值高于约100 cm或腹部矢状径值> 25 cm最有可能与潜在的“致动脉粥样硬化”代谢紊乱相关。