Kligman A M, Leyden J J
Department of Dermatology, University of Pennsylvania, School of Medicine, Philadelphia 19104.
Skin Pharmacol. 1993;6 Suppl 1:78-82. doi: 10.1159/000211167.
Once-daily application of tretinoin to photodamaged facial skin for 0-12 months results in substantial clinical and histologic improvement. As regards appearance, fine wrinkles become effaced, dyspigmentations fade, surface becomes smooth and develops a 'rosy glow'. Histologically, atrophy and dysplasia of the epidermis are completely corrected. New collagen is laid down subepidermally along with the development of new small vessels (angiogenesis). Mesenchymal dermal cells become more numerous and larger. The sum of changes is toward more youthful skin.
每天一次将维甲酸应用于光损伤的面部皮肤0至12个月，可带来显著的临床和组织学改善。在外观方面，细纹消失，色素沉着减退，皮肤表面变得光滑并呈现出“红润光泽”。在组织学上，表皮萎缩和发育异常得到完全纠正。新的胶原蛋白在表皮下沉积，同时伴有新的小血管形成（血管生成）。间充质真皮细胞数量增多且体积增大。这些变化的总和使皮肤更显年轻。
