Kotrajaras R, Kligman A M
University of Pennsylvania, School of Medicine, Department of Dermatology, Philadelphia 19104.
Br J Dermatol. 1993 Sep;129(3):302-9. doi: 10.1111/j.1365-2133.1993.tb11851.x.
Because of the climate in Bangkok, Thailand, a prematurely aged appearance is common in adults beyond 40 years of age. Sixty-one Thai people with moderate to severe signs of dermatoheliosis applied 0.05% tretinoin cream to the face once daily for 6-12 months. Four-mm punch biopsies were obtained from the cheeks before and after treatment. These were formalin-fixed and evaluated histochemically. A surprising degree of photodamage was noted histologically in these dark-skinned people. After 6 months of tretinoin, epidermal atypia and atrophy were largely corrected. There was a great diminution in the density of melanin granules within keratinocytes and corneocytes. Tretinoin did not significantly affect the dermal matrix after 6 months. However, after 12 months, a thin band of new collagen was deposited beneath the epidermis, accompanied by the formation of new vessels (angiogenesis). By global assessment, after 12 months most subjects experienced at least moderate improvement in appearance, especially with regard to hyperpigmented spots and fine wrinkles.
由于泰国曼谷的气候，40岁以上的成年人普遍呈现过早衰老的外观。61名有中度至重度皮肤光老化迹象的泰国人，每天在面部涂抹一次0.05%的维甲酸乳膏，持续6至12个月。在治疗前后从脸颊获取4毫米的钻孔活检组织。这些组织用福尔马林固定并进行组织化学评估。在这些深色皮肤的人群中，组织学上发现了令人惊讶程度的光损伤。维甲酸治疗6个月后，表皮异型性和萎缩在很大程度上得到纠正。角质形成细胞和角质层细胞内黑色素颗粒的密度大幅降低。6个月后，维甲酸对真皮基质没有显著影响。然而，12个月后，一条新的胶原薄带沉积在表皮下方，同时伴有新血管形成（血管生成）。通过整体评估，12个月后，大多数受试者的外观至少有中度改善，尤其是在色素沉着斑和细纹方面。
