Maher J, Browne P, Daly L, McCann S R, Daly P A
Department of Clinical Haematology/Oncology, St. James's Hospital, Dublin, Ireland.
Support Care Cancer. 1993 Mar;1(2):98-100. doi: 10.1007/BF00366903.
Four-hourly temperature charts relating to 63 febrile neutropenic episodes in 32 patients were assessed for a circadian distribution to the onset of fever (> 37.5 degrees C) using the Edward's test. A highly significant distribution was found with the maximum incidence of febrile events between the hours of 5 p.m. and midnight (acrophase 9.30 p.m.). Patients were 5.53 times more likely to develop fever at 9.30 p.m. that 9.30 a.m.
对32例患者63次发热性中性粒细胞减少发作的每四小时体温图表进行评估，采用爱德华兹检验确定发热（>37.5摄氏度）发作的昼夜分布情况。结果发现分布具有高度显著性，发热事件的最高发生率出现在下午5点至午夜之间（体温高峰相位为晚上9点30分）。患者在晚上9点30分出现发热的可能性是上午9点30分的5.53倍。
