Jones S M, Sampson H A
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Clin Rev Allergy. 1993 Winter;11(4):471-90.
AD is a disorder that affects up to 12% of the pediatric population. This disease is multifactorial and encompasses a wide array of etiologic factors. Strong evidence has existed in the literature over the past century for the role of inhalant and food allergies in the pathogenesis of AD. Much work is currently ongoing to delineate the role of individual cellular components, cytokines, and other mediators in the pathogenesis of AD. The answers to these questions, as well as a more comprehensive understanding of hereditary factors, will provide key information to our overall understanding of AD and our ability to treat patients with this disease more effectively in the future.
特应性皮炎是一种影响高达12%儿童群体的疾病。这种疾病是多因素的，包含一系列病因。在过去的一个世纪里，文献中已有充分证据表明吸入性和食物过敏在特应性皮炎发病机制中的作用。目前正在进行大量工作来阐明个体细胞成分、细胞因子和其他介质在特应性皮炎发病机制中的作用。这些问题的答案，以及对遗传因素更全面的理解，将为我们全面了解特应性皮炎以及未来更有效地治疗该疾病患者提供关键信息。
