肉芽肿性皮肤松弛症：细胞遗传学与分子分析

Granulomatous slack skin: cytogenetic and molecular analyses.

作者信息

Grammatico P, Balus L, Scarpa S, Varesco L, Di Rosa C, Grammatico B, Del Porto G

机构信息

Dipartimento di Medicina Sperimentale, Universita La Sapienza, Rome, Italy.

出版信息

Cancer Genet Cytogenet. 1994 Feb;72(2):96-100. doi: 10.1016/0165-4608(94)90122-8.

DOI:10.1016/0165-4608(94)90122-8

PMID:8143283

Abstract

Granulomatous slack skin (GSS) is a rare disorder which is considered a slowly evolving T-cell lymphoma associated with granulomatous inflammation that mediates clastolysis. A combined cytogenetic, molecular, and cellular analysis was conducted on a clinically and histologically defined case of GSS. Cell cultures obtained from the skin biopsy showed trisomy of chromosome 8, and the DNA sample extracted from the skin biopsy showed a T-cell receptor beta-chain rearrangement.

摘要

肉芽肿性皮肤松弛症（GSS）是一种罕见的疾病，被认为是一种与介导弹力纤维溶解的肉芽肿性炎症相关的缓慢进展的T细胞淋巴瘤。对一例临床和组织学确诊的GSS病例进行了细胞遗传学、分子和细胞联合分析。从皮肤活检获得的细胞培养显示8号染色体三体性，从皮肤活检提取的DNA样本显示T细胞受体β链重排。