Janghorbani M, Hedley A J, Jones R B, Zhianpour M, Gilmour W H
Department of Public Health, University of Glasgow, UK.
Int J Epidemiol. 1993 Dec;22(6):1056-63. doi: 10.1093/ije/22.6.1056.
The gender differential in mortality from all causes, cardiovascular disease (CVD), ischaemic heart disease (IHD) and stroke during the mean follow-up of 11.6 years (range 10-14) was examined among 4696 men and 5714 women aged 45-64 at entry in West of Scotland. Overall mortality was 19.4/1000 person-years of observation among men and 10.8/1000 person-years among women. A multiple logistic regression model was used to control the influence of gender, along with seven other cardiovascular risk factors simultaneously. The risk factors considered were age, systolic (SBP) and diastolic blood pressure (DBP), serum cholesterol, causal blood glucose, body mass index (BMI) and cigarette smoking. Both the prevalence of risk factors and relative mortality risk associated with them differed by gender. Adjustment slightly reduced the gender differential in overall mortality from 2 to 1.9 and from 1.5 to 1.4 for stroke deaths. Multiple logistic regression increased minimally the gender differential for mortality from 2.4 to 2.8 for CVD and from 2.8 to 3.4 for IHD, suggesting that these cardiovascular risk factors do not account for the overall gender difference in mortality rates. Age, SBP, DBP, blood glucose and cigarette smoking were significant predictors of mortality for both genders. Serum cholesterol was a statistically significant predictor of CVD death only for men.
在苏格兰西部，对4696名男性和5714名年龄在45 - 64岁之间的女性进行了平均11.6年（范围10 - 14年）的随访，研究了所有原因、心血管疾病（CVD）、缺血性心脏病（IHD）和中风导致的死亡的性别差异。男性的总死亡率为每1000人年观察期19.4例，女性为每1000人年10.8例。使用多元逻辑回归模型同时控制性别以及其他七个心血管危险因素的影响。所考虑的危险因素包括年龄、收缩压（SBP）和舒张压（DBP）、血清胆固醇、血糖、体重指数（BMI）和吸烟。危险因素的患病率及其相关的相对死亡风险因性别而异。调整后，总体死亡率的性别差异略有降低，从2降至1.9，中风死亡的性别差异从1.5降至1.4。多元逻辑回归使CVD死亡率的性别差异从2.4略微增加到2.8，IHD死亡率的性别差异从2.8增加到3.4，这表明这些心血管危险因素不能解释死亡率的总体性别差异。年龄、SBP、DBP、血糖和吸烟是两性死亡率的显著预测因素。血清胆固醇仅是男性CVD死亡的统计学显著预测因素。
