Palmer A, Bulpitt C, Beevers G, Coles E, Fletcher A, Ledingham J, Petrie J, Webster J, Dollery C
Division of Geriatric Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Birmingham, UK.
J Hum Hypertens. 1995 Aug;9(8):695-7.
We investigated the predictors of cardiovascular mortality at different ages in a longitudinal study of 10186 hypertensive patients attending clinics in the UK. There were 7374 patients (51% were men) < 60 years of age and 2799 patients (44% men) were > or = 60 years. For IHD death the age-adjusted relative risks (RRs) and 95% confidence intervals (CI) for a 1 mmol/l increase in cholesterol were RR = 1.17 (1.07, 1.27) (men) and RR = 1.22 (1.12, 1.33) (women). The RRs for stroke were 0.99 (men) and 1.07 (women). In men and younger women, urea and smoking were important predictors of IHD and stroke death. Age differences were present in women for both urea and smoking. For IHD in women, smoking: RR = 2.65 (1.80, 3.89) (< 60 years) and RR = 1.38 (1.01, 1.88) (> or = 60 years). For stroke in women, smoking: RR = 2.03 (1.23, 3.35) (< 60 years) and RR = 1.06 (0.70, 1.61) (> or = 60 years). We conclude that urea and smoking are important risk factors for stroke and IHD death in hypertensive women aged < 60 years, but are less important in those aged over 60 years. Cholesterol predicted IHD death in all men and women, but did not predict stroke death.
我们在一项对英国诊所中10186名高血压患者的纵向研究中，调查了不同年龄心血管死亡率的预测因素。年龄小于60岁的患者有7374名（51%为男性），年龄大于或等于60岁的患者有2799名（44%为男性）。对于缺血性心脏病（IHD）死亡，胆固醇每升高1 mmol/l，年龄调整后的相对风险（RRs）及95%置信区间（CI）为：男性RR = 1.17（1.07, 1.27），女性RR = 1.22（1.12, 1.33）。中风的RRs为：男性0.99，女性1.07。在男性和年轻女性中，尿素和吸烟是IHD和中风死亡的重要预测因素。女性在尿素和吸烟方面存在年龄差异。对于女性IHD，吸烟：RR = 2.65（1.80, 3.89）（< 60岁），RR = 1.38（1.01, 1.88）（≥ 60岁）。对于女性中风，吸烟：RR = 2.03（1.23, 3.35）（< 60岁），RR = 1.06（0.70, 1.61）（≥ 60岁）。我们得出结论，尿素和吸烟是60岁以下高血压女性中风和IHD死亡的重要危险因素，但在60岁以上女性中重要性较低。胆固醇可预测所有男性和女性的IHD死亡，但不能预测中风死亡。
