γ干扰素、腺苷脱氨酶和CA125作为结核性胸膜炎诊断参数的比较研究

A comparison study of IFN-gamma, ADA, and CA125 as the diagnostic parameters in tuberculous pleuritis.

作者信息

Aoki Y, Katoh O, Nakanishi Y, Kuroki S, Yamada H

机构信息

Department of Internal Medicine, Saga Medical School, Japan.

出版信息

Respir Med. 1994 Feb;88(2):139-43. doi: 10.1016/0954-6111(94)90027-2.

DOI:10.1016/0954-6111(94)90027-2

PMID:8146413

Abstract

Adenosine deaminase in pleural fluid (pADA), CA125 in serum (sCA125), and IFN-gamma in pleural fluid (pIFN-gamma) were measured in patients with pleurisy of various causes to evaluate their diagnostic utility in tuberculous pleuritis (TBP). We studied 39 pleural fluid samples, including 11 TBP and 28 non-TBP. With both pADA and sCA125, although the median values were much higher in TBP than in non-TBP groups, there was considerable overlap between the two groups. The sensitivity, specificity, and diagnostic efficiency were 81.8%, 89.3%, and 87.2%, respectively, when pADA values of more than 45 U ml-1 were considered, and they were 100%, 75.0%, and 84.2%, respectively, when sCA125 values of more than 35 U ml-1 were considered. In contrast, pIFN-gamma values were significantly higher in TBP patients (5.8 +/- 3.0 IU ml-1; mean +/- S.D.) than those in non-TBP patients (< 0.3 IU ml-1), leading to both a sensitivity and a specificity of 100%.

摘要

对各种病因引起胸膜炎的患者，检测其胸腔积液中的腺苷脱氨酶（pADA）、血清中的CA125（sCA125）以及胸腔积液中的干扰素-γ（pIFN-γ），以评估它们在结核性胸膜炎（TBP）中的诊断效用。我们研究了39份胸腔积液样本，其中11份为结核性胸膜炎，28份为非结核性胸膜炎。对于pADA和sCA125，尽管结核性胸膜炎组的中位数远高于非结核性胸膜炎组，但两组之间有相当大的重叠。当pADA值大于45 U/ml时，敏感性、特异性和诊断效率分别为81.8%、89.3%和87.2%；当sCA125值大于35 U/ml时，它们分别为100%、75.0%和84.2%。相比之下，结核性胸膜炎患者的pIFN-γ值（5.8±3.0 IU/ml；均值±标准差）显著高于非结核性胸膜炎患者（<0.3 IU/ml），敏感性和特异性均为100%。