Cooke R G, Ahmad N
Department of Veterinary Preclinical Sciences, University of Liverpool Veterinary Field Station, Leahurst, South Wirral, Cheshire.
Res Vet Sci. 1994 Jan;56(1):95-9. doi: 10.1016/0034-5288(94)90202-x.
Increased peripheral plasma concentrations of testosterone were detected in goats on days 13 and 14 of the oestrous cycle (oestrus = day 0), at the onset of luteolysis. Subcutaneous administration of spironolactone (10 mg kg-1 day-1) on days 10 to 19 inhibited the increases in testosterone, delayed luteolysis and suppressed plasma concentrations of 13,14-dihydro-15-keto-prostaglandin F2 alpha and oxytocin. These results suggest that testosterone of follicular or luteal origin, possibly via aromatisation to oestrogens, is needed to expedite luteolysis and induce oestrus in the goat.
在发情周期的第13天和第14天（发情日=第0天），即黄体溶解开始时，检测到山羊外周血浆睾酮浓度升高。在第10至19天皮下注射螺内酯（10毫克/千克/天）可抑制睾酮的升高，延迟黄体溶解，并抑制13,14-二氢-15-酮-前列腺素F2α和催产素的血浆浓度。这些结果表明，卵泡或黄体来源的睾酮可能通过芳香化转化为雌激素，是加速山羊黄体溶解和诱导发情所必需的。
