Cooke R G, Benhaj K M
Department of Veterinary Physiology and Pharmacology, University of Liverpool.
Res Vet Sci. 1988 Sep;45(2):222-4.
Increased peripheral plasma concentrations of testosterone were detected at the commencement of luteolysis and at oestrus in sheep. Daily subcutaneous administration of spironolactone (10 mg kg-1) between days 10 and 16 of the oestrous cycle suppressed testosterone secretion and delayed luteolysis and oestrus. In pregnant ewes no increases in testosterone concentrations occurred between days 10 to 16 after mating and luteal regression, monitored by peripheral progesterone concentrations, was inhibited. It is suggested that aromatisation of testosterone to oestrogens is needed for luteolysis in sheep.
在绵羊黄体溶解开始时和发情期检测到外周血浆睾酮浓度升高。在发情周期的第10至16天每天皮下注射螺内酯（10毫克/千克）可抑制睾酮分泌，并延迟黄体溶解和发情。在怀孕母羊中，交配后第10至16天睾酮浓度没有升高，通过外周孕酮浓度监测发现黄体退化受到抑制。研究表明，绵羊黄体溶解需要睾酮芳香化为雌激素。
