Homeida A M
J Reprod Fertil. 1986 Jan;76(1):153-7. doi: 10.1530/jrf.0.0760153.
In non-pregnant goats, appreciable amounts of testosterone (2.1 ng/g) and 5 alpha-dihydrotestosterone (DHT, 0.8 ng/g) were present in the corpus luteum on Day 12 of the oestrous cycle. Significant (P less than 0.01, N = 18) veno-arterial concentration differences of testosterone were found across ovaries bearing corpora lutea. No such difference in testosterone concentration occurred across ovaries without corpora lutea (P greater than 0.5, N = 12). Increased peripheral plasma concentrations of testosterone and DHT occurred at the start of luteal regression, as monitored by progesterone concentration, and before the day of oestrus. Subcutaneous injections of spironolactone (10 mg/kg/day) in peanut oil between Days 10 and 20 of the oestrous cycle inhibited the increase in testosterone and DHT concentrations and delayed luteolysis and oestrus. It is suggested that aromatization of testosterone to oestrogens is needed for luteal regression and expression of oestrus in goats.
在未怀孕的山羊中，发情周期第12天时，黄体中存在相当数量的睾酮（2.1纳克/克）和5α-双氢睾酮（DHT，0.8纳克/克）。在有黄体的卵巢中，发现睾酮存在显著的（P<0.01，N = 18）静脉-动脉浓度差异。在没有黄体的卵巢中，睾酮浓度没有这种差异（P>0.5，N = 12）。如通过孕酮浓度监测所示，在黄体退化开始时以及发情日之前，外周血浆中睾酮和DHT的浓度升高。在发情周期的第10至20天之间，皮下注射花生油中的螺内酯（10毫克/千克/天）可抑制睾酮和DHT浓度的升高，并延迟黄体溶解和发情。提示睾酮向雌激素的芳香化作用对于山羊的黄体退化和发情表达是必需的。
