日粮镁对猪骨骼肌死后磷酸肌酸利用的影响：一项使用31P-NMR光谱法的非侵入性研究。
Effect of dietary magnesium on post mortem phosphocreatine utilization in skeletal muscle of swine: a non-invasive study using 31P-NMR spectroscopy.
作者信息
Moesgaard B, Larsen I E, Quistorff B, Therkelsen I, Christensen V G, Jørgensen P F
机构信息
Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
出版信息
Acta Vet Scand. 1993;34(4):397-404. doi: 10.1186/BF03548184.
The effect of dietary magnesium on the post mortem PCr (phosphocreatine) decay in muscle of heterozygote malignant hyperthermia pigs was studied after in vivo exposure to a combination of halothane and succinylcholine. The pigs were anaesthetized with halothane and succinylcholine was injected in the ear vein. Immediately after initiation of the depolarizing neuromuscular blocking effect of succinylcholine the animals were captive-bolt stunned. The PCr decay, reflecting ATP turnover, was followed in situ by 31P-NMR spectroscopy in the biceps femoris muscle for the subsequent 40-70 min post mortem. In 3 of the 4 experiments, the Mg-fed pig had a significantly reduced rate of PCr hydrolysis compared to the control animal. The mechanism of this magnesium effect is unknown.
研究了在体内暴露于氟烷和琥珀酰胆碱的组合后，日粮镁对杂合子恶性高热猪肌肉中死后磷酸肌酸（PCr）衰减的影响。用氟烷麻醉猪，并通过耳静脉注射琥珀酰胆碱。在琥珀酰胆碱开始产生去极化神经肌肉阻滞作用后，立即用枪击毙动物致其昏迷。通过31P-NMR光谱法在死后40-70分钟内原位跟踪股二头肌中反映ATP周转的PCr衰减情况。在4个实验中的3个实验中，与对照动物相比，摄入镁的猪的PCr水解速率显著降低。这种镁效应的机制尚不清楚。
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