Li R, Chen X, Yan H, Deurenberg P, Garby L, Hautvast J G
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing.
Am J Clin Nutr. 1994 Apr;59(4):908-13. doi: 10.1093/ajcn/59.4.908.
Eighty iron-deficient, nonpregnant female workers were randomly assigned to ferrous sulphate (60 or 120 mg Fe/d) or placebo treatment for 12 wk. Energy expenditure was estimated during 3 d by heart rate (HR) recording. Production efficiency (PE) was calculated as the ratio of productivity to energy expenditure. In the iron-treated group mean hemoglobin (Hb) increased from 114 to 127 g/L (P < 0.001), mean serum ferritin increased from 9.7 to 30.0 micrograms/L (P < 0.001), and mean free erythrocyte protoporphyrin decreased from 1.01 to 0.49 mumol/L (P < 0.001). Mean HR at work decreased from 95.5 to 91.1 beats/min (P < 0.001), which was inversely correlated with the change in Hb (r = -0.60, P < 0.001). PE increased significantly in the iron-treated group (P < 0.001) and its change paralleled the change in Hb (r = 0.58, P < 0.001). The results show that iron supplementation enabled these women to do the same work at a lower energy cost.
80名缺铁的非孕女性工人被随机分为硫酸亚铁组（60或120毫克铁/天）或安慰剂组，治疗12周。通过记录心率估计3天内的能量消耗。生产效率（PE）计算为生产力与能量消耗之比。铁治疗组的平均血红蛋白（Hb）从114克/升增加到127克/升（P<0.001），平均血清铁蛋白从9.7微克/升增加到30.0微克/升（P<0.001），平均游离红细胞原卟啉从1.01微摩尔/升降至0.49微摩尔/升（P<0.001）。工作时的平均心率从95.5次/分钟降至91.1次/分钟（P<0.001），这与Hb的变化呈负相关（r = -0.60，P<0.001）。铁治疗组的PE显著增加（P<0.001），其变化与Hb的变化平行（r = 0.58，P<0.001）。结果表明，补充铁使这些女性能够以较低的能量成本完成相同的工作。
