Matsumoto R, Mulkern R V, Hushek S G, Jolesz F A
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
J Magn Reson Imaging. 1994 Jan-Feb;4(1):65-70. doi: 10.1002/jmri.1880040114.
For thermal interventional therapy, near real-time monitoring of temperature changes in the treated area is desirable. In this study, various fast T1-weighted magnetic resonance (MR) imaging protocols were compared to determine the sensitivity and resolution of signal intensity for temperatures within the range of 36 degrees C-66 degrees C in gel phantoms and in vitro porcine liver specimens. The results showed that a T1-weighted fast spin-echo sequence with a TR of 100 msec had better temperature sensitivity and resolution than other sequences with comparable temporal resolutions. The longer imaging times required for fast spin-echo sequences with a TR of 300 msec did not improve temperature sensitivity. The methods introduced to evaluate temperature sensitivity and resolution should prove useful in selecting appropriate MR protocols for monitoring thermal treatment modalities such as interstitial laser therapy, focused ultrasound therapy, or radio-frequency heating.
对于热介入治疗，对治疗区域内的温度变化进行近实时监测是很有必要的。在本研究中，比较了各种快速T1加权磁共振（MR）成像协议，以确定凝胶体模和体外猪肝标本中36℃至66℃范围内温度的信号强度灵敏度和分辨率。结果表明，重复时间（TR）为100毫秒的T1加权快速自旋回波序列比具有可比时间分辨率的其他序列具有更好的温度灵敏度和分辨率。TR为300毫秒的快速自旋回波序列所需的较长成像时间并未提高温度灵敏度。所介绍的评估温度灵敏度和分辨率的方法在选择合适的MR协议以监测诸如间质激光治疗、聚焦超声治疗或射频加热等热治疗方式时应会证明是有用的。
