Faulkner K G, McClung M R, Coleman L J, Kingston-Sandahl E
Providence Center for Osteoporosis Research, Portland, OR 97213-2966.
Osteoporos Int. 1994 Jan;4(1):42-7. doi: 10.1007/BF02352260.
To assess the utility of quantitative ultrasound (QUS) of the heel for osteoporosis screening, we studied a group of 170 early postmenopausal women using both QUS of the heel and dual-energy X-ray absorptiometry (DXA) at the spine, hip, forearm, and whole body. On the basis of the linear regression results between QUS and DXA, a 95% bone mineral density (BMD) estimate confidence range was defined. Correlation coefficients between the QUS measurements and DXA ranged from 0.26 to 0.63. The confidence ranges for the estimated BMD based on a QUS measurement of the heel were large, such that an estimation of skeletal BMD at any of the DXA sites measured was not possible. For example, an estimate of the normative anteroposterior spine BMD (i.e. the T-score or the Z-score) based on a calcaneal ultrasound reading would have an error of +/- 1.9 standard deviations. Results for predicting the normative BMD of the other DXA regions were similar, with expected errors ranging from +/- 1.4 to +/- 2.0 standard deviations. We therefore conclude that QUS is not suited for the screening of early postmenopausal women for low axial or peripheral BMD. However, QUS may have a role as an independent predictor of fracture by measuring skeletal properties in addition to bone density.
为评估足跟定量超声（QUS）用于骨质疏松症筛查的效用，我们对一组170名绝经后早期女性进行了研究，采用足跟QUS以及脊柱、髋部、前臂和全身的双能X线吸收法（DXA）。根据QUS与DXA之间的线性回归结果，定义了95%骨矿物质密度（BMD）估计置信范围。QUS测量值与DXA之间的相关系数范围为0.26至0.63。基于足跟QUS测量的估计BMD置信范围很大，以至于无法对任何测量的DXA部位的骨骼BMD进行估计。例如，基于跟骨超声读数对正常前后位脊柱BMD（即T评分或Z评分）的估计误差为±1.9个标准差。预测其他DXA区域正常BMD的结果类似，预期误差范围为±1.4至±2.0个标准差。因此，我们得出结论，QUS不适合用于筛查绝经后早期女性的低轴向或外周BMD。然而，QUS除了测量骨密度外，还可通过测量骨骼特性作为骨折的独立预测指标。
