Goto K, Kato S, Sumiya S, Uehara S, Hirayama A, Sakamoto W, Tokumitsu Y, Takada M
Department of Pharmacy, Tonan Hospital, Sapporo, Japan.
Biol Pharm Bull. 1994 Jan;17(1):142-5. doi: 10.1248/bpb.17.142.
Urinary gamma-carboxyglutamic acid (gamma-Gla) levels were determined in healthy subjects of all ages. The urinary gamma-Gla levels were highest in infants (0-1 years), then fell in an age-dependent manner, again in subjects reaching a minimum value in adults, then gradually increased over 60 years of age. Urinary gamma-Gla levels therefore change markedly with aging. The relationships between the urinary gamma-Gla excretion and plasma levels of prothrombin and protein C in patients with various hepatic diseases or diabetes mellitus were examined and compared with those in healthy adults. Both plasma prothrombin and protein C levels were decreased in all patients with liver disease compared with healthy adults. In patients with hepatitis and liver cirrhosis, the decrease did not, however, affect the gamma-Gla excretion. In addition, in patients with hepatoma or carcinoma with liver metastases, the urinary gamma-Gla levels were increased. In patients with diabetes mellitus, the urinary gamma-Gla levels and plasma levels of prothrombin and protein C tended to increase, but this was not significant. The present results indicate that simultaneous measurement of the levels of urinary gamma-Gla and plasma prothrombin and protein C is a useful tool for the diagnosis of liver diseases and diabetes mellitus.
测定了各年龄段健康受试者尿中γ-羧基谷氨酸（γ-Gla）水平。尿γ-Gla水平在婴儿（0 - 1岁）中最高，然后以年龄依赖性方式下降，在成年人中降至最低值，之后在60岁以上逐渐升高。因此，尿γ-Gla水平随年龄增长而显著变化。研究了各种肝病或糖尿病患者尿γ-Gla排泄与血浆凝血酶原和蛋白C水平之间的关系，并与健康成年人进行了比较。与健康成年人相比，所有肝病患者的血浆凝血酶原和蛋白C水平均降低。然而，在肝炎和肝硬化患者中，这种降低并未影响γ-Gla排泄。此外，在肝癌或有肝转移的癌症患者中，尿γ-Gla水平升高。在糖尿病患者中，尿γ-Gla水平以及血浆凝血酶原和蛋白C水平有升高趋势，但并不显著。目前的结果表明，同时测定尿γ-Gla、血浆凝血酶原和蛋白C水平是诊断肝病和糖尿病的有用工具。
