Dev S, Adler A J, Edwards R B
Department of Ophthalmology L-907, Boston University School of Medicine, MA 02118.
Brain Res. 1993 Dec 31;632(1-2):325-8. doi: 10.1016/0006-8993(93)91170-w.
Tissues of adult rabbit brain were shown to enzymatically oxidize retinol and retinaldehyde to retinoic acid, a potent stimulator of gene expression. Rates of retinoic acid synthesis by the cerebrum, cerebellum, and meninges were comparable to, or exceeded, rates measured with rat liver, an organ known to have a relatively high capacity to synthesize retinoic acid. These results, taken together with previous observations that the adult brain contains retinoic acid-activated transcription factors and cellular retinoid-binding proteins, suggest that retinoids may play an important role in the adult central nervous system.
成年兔脑的组织被证明能将视黄醇和视黄醛酶促氧化为视黄酸，视黄酸是一种强大的基因表达刺激剂。大脑、小脑和脑膜合成视黄酸的速率与已知具有相对较高视黄酸合成能力的大鼠肝脏所测得的速率相当或超过该速率。这些结果，连同之前观察到的成人大脑中含有视黄酸激活的转录因子和细胞类视黄醇结合蛋白，表明类视黄醇可能在成体中枢神经系统中发挥重要作用。
