Noel M B, Wise R A
Department of Psychology, Concordia University, Montreal, Que., Canada.
Brain Res. 1993 Dec 31;632(1-2):68-73. doi: 10.1016/0006-8993(93)91139-j.
Food-deprived rats received microinjections of the preferential mu opiate morphine or the selective kappa opiate U-50,488H (0.1, 1 and 10 nmol) into the ventral tegmental area (VTA). Meals were divided into discrete segments so that repeated measures of the speed of eating and the latency to initiate eating could be obtained. Morphine produced a dose-dependent increase in the speed of eating. Injections of saline or U-50,488H into the VTA or injections of morphine dorsal to the VTA were ineffective. Neither morphine nor U-50,488H had a significant effect on the latency to initiate feeding. These data suggest that mu but not kappa opioid receptors in the VTA are involved in the regulation of feeding in food-deprived rats.
对食物匮乏的大鼠，在腹侧被盖区（VTA）进行微量注射，注射优先性μ阿片类药物吗啡或选择性κ阿片类药物U - 50,488H（0.1、1和10纳摩尔）。将餐食分成离散的部分，以便能够获得进食速度和开始进食潜伏期的重复测量值。吗啡使进食速度呈剂量依赖性增加。向VTA注射生理盐水或U - 50,488H，或在VTA背侧注射吗啡均无效。吗啡和U - 50,488H对开始进食的潜伏期均无显著影响。这些数据表明，VTA中的μ阿片受体而非κ阿片受体参与了食物匮乏大鼠的进食调节。
