Wang H L
Laboratory for Thrombosis and Haemostasis Research, Shanghai Institute of Hematology, Shanghai Second Medical University.
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1993 Nov;9(6):441-6, 479.
78 burned patients (53 males and 25 females) were classified into 4 groups (mild: 14 cases, moderate: 13 cases, severe: 17 cases and extra--severe: 34 cases) in accordance with criteria established by the Chinese Society for Burns. 22 parameters related to platelet, coagulant and anticoagulant factors, fibrinolysis system and hemorheology were determined in the first 24 hours, and on the third and fifth post burn days. The results were as follows: Fibrinogen antigen, von Willebrand factor antigen, plasminogen activator inhibitor activity, thromboxane B2 and hematocrit and whole blood viscosity significantly increased, while antithrombin III, protein C antigen, free protein S and 6-Keto-prostaglandin F1 alpha markedly decreased as compared with normal control in the first 24 hours postburn. In addition, fibrinogen antigen, von Willebrand factor antigen, plasminogen inhibitor activity, thromboxane B2 and whole blood viscosity were persistently elevated, while antithrombin III, protein C, free protein S and 6-Keto-prostaglandin F1 alpha declined on the third and fifth postburn days. These changes resulted in a prethrombotic state, which might be an important factor in the pathogenesis of microthrombosis in burn sites, resulting in deepening of burn wound on the third and fifth days in burn patients.
78例烧伤患者（男53例，女25例），按照中国烧伤学会制定的标准分为4组（轻度：14例，中度：13例，重度：17例，特重度：34例）。在伤后24小时内以及烧伤后第3天和第5天，测定了与血小板、凝血及抗凝因子、纤溶系统和血液流变学相关的22项参数。结果如下：与正常对照组相比，烧伤后24小时内纤维蛋白原抗原、血管性血友病因子抗原、纤溶酶原激活物抑制物活性、血栓素B2、血细胞比容和全血粘度显著升高，而抗凝血酶III、蛋白C抗原、游离蛋白S和6-酮-前列腺素F1α明显降低。此外，在烧伤后第3天和第5天，纤维蛋白原抗原、血管性血友病因子抗原、纤溶酶原抑制物活性、血栓素B2和全血粘度持续升高，而抗凝血酶III、蛋白C、游离蛋白S和6-酮-前列腺素F1α下降。这些变化导致了血栓前状态，这可能是烧伤部位微血栓形成发病机制中的一个重要因素，导致烧伤患者在烧伤后第3天和第5天烧伤创面加深。
