Burke Y D, Stark M J, Roach S L, Sen S E, Crowell P L
Department of Biology, Indiana University-Purdue University at Indianapolis 46202, USA.
Lipids. 1997 Feb;32(2):151-6. doi: 10.1007/s11745-997-0019-y.
Fruits and vegetables have protective effects against many human cancers, including pancreatic cancer. Isoprenoids are one class of phytochemicals which have antitumor activity, but little is known about their effects on cancer of the pancreas. We tested the hypothesis that isoprenoids would inhibit the growth of pancreatic tumor cells. Significant (60-90%) inhibition of the anchorage-independent growth of human MIA PaCa2 pancreatic tumor cells was attained with 25 microM farnesol, 25 microM geranylgeraniol, 100 microM perillyl amine, 100 microM geraniol, or 300 microM perillyl alcohol. We then tested the relative in vivo antitumor activities of dietary farnesol, geraniol, and perillyl alcohol against transplanted PC-1 hamster pancreatic adenocarcinomas. Syrian Golden hamsters fed geraniol or farnesol at 20 g/kg diet exhibited complete inhibition of PC-1 pancreatic tumor growth. Both farnesol and geraniol were more potent than perillyl alcohol, which inhibited tumor growth by 50% at 40 g/kg diet. Neither body weights nor plasma cholesterol levels of animals consuming isoprenoid diets were significantly different from those of pair-fed controls. Thus, farnesol, geraniol, and perillyl alcohol suppress pancreatic tumor growth without significantly affecting blood cholesterol levels. These dietary isoprenoids warrant further investigation for pancreatic cancer prevention and treatment.
水果和蔬菜对包括胰腺癌在内的多种人类癌症具有保护作用。类异戊二烯是一类具有抗肿瘤活性的植物化学物质，但人们对它们对胰腺癌的影响知之甚少。我们检验了类异戊二烯会抑制胰腺肿瘤细胞生长的假说。25微摩尔法尼醇、25微摩尔香叶基香叶醇、100微摩尔紫苏胺、100微摩尔香叶醇或300微摩尔紫苏醇可显著（60 - 90%）抑制人MIA PaCa2胰腺肿瘤细胞的非锚定依赖性生长。然后，我们测试了膳食中的法尼醇、香叶醇和紫苏醇对移植的PC - 1仓鼠胰腺腺癌的相对体内抗肿瘤活性。以20克/千克饮食喂食香叶醇或法尼醇的叙利亚金仓鼠的PC - 1胰腺肿瘤生长完全受到抑制。法尼醇和香叶醇都比紫苏醇更有效，紫苏醇在40克/千克饮食时可抑制肿瘤生长50%。食用类异戊二烯饮食的动物的体重和血浆胆固醇水平与配对喂食的对照组相比均无显著差异。因此，法尼醇、香叶醇和紫苏醇可抑制胰腺肿瘤生长，而不会显著影响血液胆固醇水平。这些膳食类异戊二烯在胰腺癌预防和治疗方面值得进一步研究。
