Sobral Marianna Vieira, Xavier Aline Lira, Lima Tamires Cardoso, de Sousa Damião Pergentino
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, 58051-970 João Pessoa, PB, Brazil ; Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Universidade Federal da Paraíba, Caixa Postal 5009, 58015-970 João Pessoa, PB, Brazil.
Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Universidade Federal da Paraíba, Caixa Postal 5009, 58015-970 João Pessoa, PB, Brazil.
ScientificWorldJournal. 2014;2014:953451. doi: 10.1155/2014/953451. Epub 2014 Oct 14.
Cancer is a complex genetic disease that is a major public health problem worldwide, accounting for about 7 million deaths each year. Many anticancer drugs currently used clinically have been isolated from plant species or are based on such substances. Accumulating data has revealed anticancer activity in plant-derived monoterpenes. In this review the antitumor activity of 37 monoterpenes found in essential oils is discussed. Chemical structures, experimental models, and mechanisms of action for bioactive substances are presented.
癌症是一种复杂的遗传性疾病，是全球主要的公共卫生问题，每年导致约700万人死亡。目前临床上使用的许多抗癌药物都是从植物物种中分离出来的，或者是基于此类物质。越来越多的数据显示植物源单萜类化合物具有抗癌活性。在这篇综述中，讨论了在香精油中发现的37种单萜类化合物的抗肿瘤活性。介绍了生物活性物质的化学结构、实验模型和作用机制。
