恶性疟原虫或间日疟原虫疟疾患者血浆中可溶性细胞间黏附分子-1（sICAM-1）、可溶性血管细胞黏附分子-1（sVCAM-1）和可溶性内皮白细胞黏附分子-1（sELAM-1）浓度升高及其与疾病严重程度的关联。
Increased plasma concentrations of sICAM-1, sVCAM-1 and sELAM-1 in patients with Plasmodium falciparum or P. vivax malaria and association with disease severity.
作者信息
Jakobsen P H, Morris-Jones S, Rønn A, Hviid L, Theander T G, Elhassan I M, Bygbjerg I C, Greenwood B M
机构信息
Department of Infectious Diseases, University Hospital (Rigshospitalet), Copenhagen, Denmark.
出版信息
Immunology. 1994 Dec;83(4):665-9.
Abstract
Increased serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), soluble endothelial leucocyte adhesion molecule-1 (sELAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were detected in Danish malaria patients infected with sequestering Plasmodium falciparum or non-sequestering P. vivax parasites, as well as in patients with sepsis or meningitis. Levels of soluble adhesion molecules remained elevated in the P. falciparum patients for several weeks after initiation of treatment. Plasma concentrations of sICAM-1, sVCAM-1 and sELAM-1 were higher in Gambian children with severe P. falciparum malaria than in children with mild malaria. Plasma levels of sVCAM-1 and sELAM-1 were significantly correlated. Plasma levels of sELAM-1 and sVCAM-1 may reflect endothelial inflammatory reactions and these reactions may be harmful for humans infected with malaria parasites.
摘要
在感染滞留型恶性疟原虫或非滞留型间日疟原虫的丹麦疟疾患者以及脓毒症或脑膜炎患者中，检测到血清中可溶性细胞间黏附分子-1（sICAM-1）、可溶性内皮白细胞黏附分子-1（sELAM-1）和可溶性血管细胞黏附分子-1（sVCAM-1）的浓度升高。在接受治疗后的数周内，恶性疟患者体内可溶性黏附分子水平持续升高。患有严重恶性疟的冈比亚儿童血浆中sICAM-1、sVCAM-1和sELAM-1的浓度高于患有轻度疟疾的儿童。血浆中sVCAM-1和sELAM-1的水平显著相关。血浆中sELAM-1和sVCAM-1的水平可能反映了内皮炎症反应，而这些反应可能对感染疟原虫的人类有害。
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