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用于鉴定来自西班牙(1989 - 92年)的耐甲氧西林金黄色葡萄球菌流行菌株的另一组噬菌体。

An additional set of phages to characterize epidemic methicillin-resistant Staphylococcus aureus strains from Spain (1989-92).

作者信息

Vindel A, Trincado P, Gomez E, Aparicio P, Martin de Nicolas M, Boquete T, Saez Nieto J A

机构信息

Laboratorio de Referencia de fagotipia de S. aureus, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

出版信息

Epidemiol Infect. 1994 Apr;112(2):299-306. doi: 10.1017/s095026880005771x.

Abstract

In recent years, methicillin-resistant Staphylococcus aureus (MRSA) isolates in Spain have increased dramatically; in 1986 there were only 1.2% MRSA amongst all nosocomial Staphylococcus aureus (SA) isolates, by 1989 this percentage had risen to 44% in some hospital causing a very serious epidemic situation in the country. We have characterized these isolates by direct, reverse and Fisk phage typing and we have also looked for an additional local set of phages to help us to differentiate these strains. We have been able to differentiate an epidemic strain from other MRSA strains which cause sporadic hospital outbreaks, and we have also distinguished between some variants of the epidemic strain.

摘要

近年来,西班牙耐甲氧西林金黄色葡萄球菌(MRSA)分离株急剧增加;1986年,在所有医院获得性金黄色葡萄球菌(SA)分离株中,MRSA仅占1.2%,到1989年,在一些医院这一比例已升至44%,在该国引发了非常严重的疫情。我们通过直接、反向和菲斯克噬菌体分型对这些分离株进行了特征分析,并且还寻找了一组额外的本地噬菌体,以帮助我们区分这些菌株。我们已经能够将流行菌株与其他导致医院散发性暴发的MRSA菌株区分开来,并且还区分了流行菌株的一些变体。

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1
Agar layer method for production of high titer phage stocks.用于生产高滴度噬菌体原液的琼脂层法。
Proc Soc Exp Biol Med. 1951 Nov;78(2):372-5. doi: 10.3181/00379727-78-19076.
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Supplementary phages for the investigation of strains of methicillin-resistant Staphylococcus aureus.
J Med Microbiol. 1988 Jan;25(1):67-74. doi: 10.1099/00222615-25-1-67.

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