Newton M, Cooper B T
Gastroenterology Unit, Dudley Road Hospital, Birmingham.
Gut. 1994 Mar;35(3):423-5. doi: 10.1136/gut.35.3.423.
Benign intracranial hypertension (BIH, pseudotumour cerebri) is a rare condition with unknown aetiology although hormonal influences have been implicated. It occurs spontaneously, particularly in young obese women, and is associated with several drug treatments including corticosteroids. Two young adult women are described in whom headache and papilloedema in association with raised intracranial pressure occurred during prednisolone treatment for inflammatory bowel disease. This provides further evidence of the risk of BIH during corticosteroid treatment and has not been described before in adults with this condition. Advice is given to gastroenterologists to use corticosteroids with caution in adults, particularly young, fertile female patients. The treatment of a severe relapse of colitis in a patient who has had one episode of steroid related BIH remains a dilemma.
良性颅内高压（BIH，假性脑瘤）是一种病因不明的罕见病症，尽管有研究认为其与激素影响有关。它可自发出现，尤其在年轻肥胖女性中，并且与包括皮质类固醇在内的多种药物治疗相关。本文描述了两名年轻成年女性，她们在接受泼尼松龙治疗炎症性肠病期间出现头痛、视乳头水肿并伴有颅内压升高。这进一步证明了皮质类固醇治疗期间发生BIH的风险，且此前尚未在患有该病症的成年人中被描述过。建议胃肠病学家在成人，尤其是年轻、有生育能力的女性患者中谨慎使用皮质类固醇。对于曾有过一次类固醇相关BIH发作的患者，治疗严重复发的结肠炎仍然是一个难题。
