Ba C, Ohshima K, Kobata K, Kamihara Y, Kobari S, Sumiyoshi Y, Takeshita M, Kikuchi M
1st Department of Pathology, School of Medicine, Fukuoka University.
Rinsho Byori. 1994 Mar;42(3):295-301.
The nasopharyngeal lymphoepithelioma is closely related with Epstein-Barr virus. The first clinical manifestation is frequently enlargement of the cervical lymph nodes of unknown origin. The histology of the metastatic lymphoepithelioma in the lymph nodes sometimes resembles those of other metastatic carcinoma and granulomatous diseases. To differentiate the lymphoepithelioma from other disorders, we detected Epstein-Barr virus (EBV), using stamp specimens. By polymerase chain reaction, all seven lymphoepitheliomas presented amplified EBV genomes, while five of the 58 other carcinomas and eight of the 19 granulomatous diseases also did. By in situ hybridization, lymphoepitheliomas showed EBV genomes which were confined to the tumor cells, though in the other diseases they were found in the lymphocytes. Detection of EBV is very useful in making a diagnosis of lymphoepitheliomas.
鼻咽淋巴上皮瘤与EB病毒密切相关。其首发临床表现常为不明原因的颈部淋巴结肿大。淋巴结转移性淋巴上皮瘤的组织学表现有时类似于其他转移性癌和肉芽肿性疾病。为了将淋巴上皮瘤与其他疾病区分开来，我们使用印片标本检测了EB病毒（EBV）。通过聚合酶链反应，所有7例淋巴上皮瘤均呈现EBV基因组扩增，而58例其他癌中的5例以及19例肉芽肿性疾病中的8例也呈现扩增。通过原位杂交，淋巴上皮瘤显示EBV基因组局限于肿瘤细胞，而在其他疾病中则在淋巴细胞中发现。检测EBV对淋巴上皮瘤的诊断非常有用。
