Compston J E, Vedi S, Croucher P I, Garrahan N J, O'Sullivan M M
Department of Rheumatology, University Hospital of Wales, Cardiff, United Kingdom.
Ann Rheum Dis. 1994 Mar;53(3):163-6. doi: 10.1136/ard.53.3.163.
To examine whether changes in cancellous bone turnover and resorption cavity depth contribute to bone loss in patients with non-steroid treated rheumatoid arthritis.
Iliac crest biopsies were obtained from 37 patients with non-steroid treated rheumatoid arthritis, 13 male and 24 female, aged 37-71 years. Bone turnover and resorption cavity characteristics were quantitatively assessed using semiautomated computerised techniques.
When compared with age- and sex-matched control values, there was a significant reduction in bone formation rate at tissue level and activation frequency (P < 0.001) in the patient group. The eroded perimeter, mean and maximum eroded depth and cavity area were also significantly reduced (P < 0.01, < 0.005, < 0.01 and < 0.005 respectively).
These results demonstrate low bone turnover in non-steroid treated rheumatoid arthritis and indicate that the reduced bone mass in these patients is due mainly to a negative remodelling balance.
研究非甾体类药物治疗的类风湿关节炎患者的松质骨转换和吸收腔深度变化是否导致骨质流失。
对37例非甾体类药物治疗的类风湿关节炎患者进行髂嵴活检，其中男性13例，女性24例，年龄37 - 71岁。使用半自动计算机技术对骨转换和吸收腔特征进行定量评估。
与年龄和性别匹配的对照值相比，患者组组织水平的骨形成率和激活频率显著降低（P < 0.001）。侵蚀周长、平均和最大侵蚀深度以及腔面积也显著降低（分别为P < 0.01、< 0.005、< 0.01和< 0.005）。
这些结果表明非甾体类药物治疗的类风湿关节炎患者骨转换率低，提示这些患者骨量减少主要是由于负性重塑平衡所致。
