肿瘤坏死因子介导人腹膜间皮细胞释放纤溶酶原激活物抑制剂1
Tumour necrosis factor-mediated release of plasminogen activator inhibitor 1 by human peritoneal mesothelial cells.
作者信息
Whawell S A, Scott-Coombes D M, Vipond M N, Tebbutt S J, Thompson J N
机构信息
Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
出版信息
Br J Surg. 1994 Feb;81(2):214-6. doi: 10.1002/bjs.1800810218.
Human mesothelial cells synthesize plasminogen activator inhibitor (PAI) 1 in inflamed peritoneal tissue. The role of tumour necrosis factor (TNF) in the mediation of this response was studied. Postoperative peritoneal drain fluid contained both TNF and PAI-1. Peak levels of TNF at 4 h (median 271 pg/ml) preceded a rise in PAI-1 concentration, which peaked at 18 h (median 943.1 ng/ml). Thus TNF may mediate increased PAI-1 release in inflamed peritoneum. TNF significantly increased the mean(s.e.m.) release of PAI-1 by human peritoneal mesothelial cells in vitro at 4 h (control 1.84(0.17) ng/micrograms versus TNF 2.37(0.17) ng/micrograms, P < 0.05), 6 h (2.53(0.09) versus 3.88(0.46) ng/micrograms, P < 0.05), 18 h (0.50(0.02) versus 1.04(0.11) ng/micrograms, P < 0.05) and 24 h (0.87(0.05) versus 1.35(0.11) ng/micrograms, P < 0.05). TNF may be an important mediator of PAI-1 production by human mesothelial cells during peritoneal inflammation.
人腹膜间皮细胞在炎症性腹膜组织中合成纤溶酶原激活物抑制剂（PAI）1。研究了肿瘤坏死因子（TNF）在介导这种反应中的作用。术后腹腔引流液中同时含有TNF和PAI-1。TNF在4小时时达到峰值水平（中位数为271 pg/ml），随后PAI-1浓度升高，PAI-1在18小时时达到峰值（中位数为943.1 ng/ml）。因此，TNF可能介导炎症腹膜中PAI-1释放增加。在体外，TNF在4小时（对照组1.84（0.17）ng/μg，TNF组2.37（0.17）ng/μg，P<0.05）、6小时（2.53（0.09）对3.88（0.46）ng/μg，P<0.05）、18小时（0.50（0.02）对1.04（0.11）ng/μg，P<0.05）和24小时（0.87（0.05）对1.35（0.11）ng/μg，P<0.05）时显著增加人腹膜间皮细胞PAI-1的平均（标准误）释放量。TNF可能是腹膜炎症期间人腹膜间皮细胞产生PAI-1的重要介质。
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