急性和慢性腹泻感染患者针对人类免疫缺陷病毒的肠道分泌型IgA免疫反应

Intestinal secretory IgA immune response against human immunodeficiency virus among infected patients with acute and chronic diarrhea.

作者信息

Mathewson J J, Jiang Z D, DuPont H L, Chintu C, Luo N, Zumla A

机构信息

Center for Infectious Diseases, University of Texas Medical School/School of Public Health, Houston 77030.

出版信息

J Infect Dis. 1994 Mar;169(3):614-7. doi: 10.1093/infdis/169.3.614.

DOI:10.1093/infdis/169.3.614

PMID:8158035

Abstract

Diarrhea is common in patients infected with the human immunodeficiency virus (HIV) in Africa. There has been speculation that HIV itself may cause some of the enteropathy seen. The intestinal secretory IgA (sIgA) response was used to evaluate HIV intestinal infections in Zambian patients with acute and chronic diarrhea. sIgA was extracted from stool specimens and evaluated by an ELISA. Seven (58%) of 12 HIV-positive patients with acute diarrhea and 25 (69%) of 36 HIV-positive patients with chronic diarrhea showed an sIgA response to HIV p24, compared with 1 of 10 HIV-positive patients without diarrhea (P < .025 for acute and P < .001 for chronic diarrhea). The mean duration of diarrhea was significantly longer in patients showing an anti-p24 response. An sIgA response to HIV antigens occurs commonly in infected patients with diarrhea and may provide further evidence of an etiologic role of HIV in the diarrhea associated with AIDS.

摘要

腹泻在非洲感染人类免疫缺陷病毒（HIV）的患者中很常见。有人推测，HIV本身可能导致部分所见的肠道病变。肠道分泌型IgA（sIgA）反应被用于评估赞比亚急性和慢性腹泻患者的HIV肠道感染情况。从粪便标本中提取sIgA，并通过酶联免疫吸附测定（ELISA）进行评估。12例急性腹泻的HIV阳性患者中有7例（58%）、36例慢性腹泻的HIV阳性患者中有25例（69%）对HIV p24呈现sIgA反应，相比之下，10例无腹泻的HIV阳性患者中仅有1例出现该反应（急性腹泻P <.025，慢性腹泻P <.001）。出现抗p24反应的患者腹泻平均持续时间显著更长。对HIV抗原的sIgA反应在感染腹泻患者中普遍存在，这可能为HIV在与艾滋病相关的腹泻中所起的病因学作用提供进一步证据。