Mathewson J J, Salameh B M, DuPont H L, Jiang Z D, Nelson A C, Arduino R, Smith M A, Masozera N
Center for Infectious Diseases, The University of Texas School of Public Health and Medical School, Houston 77030, USA.
Clin Diagn Lab Immunol. 1998 Jan;5(1):87-90. doi: 10.1128/CDLI.5.1.87-90.1998.
HEp-2 cell-adherent Escherichia coli and the human immunodeficiency virus (HIV) itself have recently been incriminated as causes of chronic HIV-associated diarrhea. This study sought to determine the prevalence of these two agents among HIV-infected patients with diarrhea in an outpatient setting in the United States and to compare their prevalence to that of other commonly recognized enteropathogens known to be present in this population. HEp-2 cell-adherent E. coli was found in 20 of 83 (24.1%) patients with diarrhea. A diffuse pattern of adherence was the most common, found in 14 of 20 (70%) patients, followed by a localized adherence pattern (6 of 20; 30%). An intestinal secretory immune response against the p24 antigen of HIV was found in 9 of 34 (27.5%) patients with HIV-associated diarrhea. The following pathogens or products were also detected in lower frequencies: Cryptosporidium spp. (10.8%), Clostridium difficile toxin (8.8%), microsporidia (6%), Isospora belli (3.6%), Blastocystis hominis (2.4%), Giardia spp. (1.2%), Salmonella spp. (1.2%), and Mycobacterium spp. (1.2%). The role of HEp-2 cell-adherent E. coli and HIV enteric infections in patients with HIV-associated diarrhea deserves further study.
人喉表皮样癌细胞黏附性大肠杆菌和人类免疫缺陷病毒（HIV）本身最近被认为是慢性HIV相关腹泻的病因。本研究旨在确定在美国门诊环境中，腹泻的HIV感染患者中这两种病原体的流行率，并将其流行率与该人群中其他常见的已知肠道病原体的流行率进行比较。在83例腹泻患者中的20例（24.1%）中发现了人喉表皮样癌细胞黏附性大肠杆菌。弥漫性黏附模式最为常见，在20例患者中的14例（70%）中发现，其次是局部黏附模式（20例中的6例；30%）。在34例HIV相关腹泻患者中的9例（27.5%）中发现了针对HIV p24抗原的肠道分泌免疫反应。还检测到以下病原体或产物的频率较低：隐孢子虫属（10.8%）、艰难梭菌毒素（8.8%）、微孢子虫（6%）、贝氏等孢球虫（3.6%）、人芽囊原虫（2.4%）、贾第虫属（1.2%）、沙门氏菌属（1.2%）和分枝杆菌属（1.2%）。人喉表皮样癌细胞黏附性大肠杆菌和HIV肠道感染在HIV相关腹泻患者中的作用值得进一步研究。
