Nikolic-Paterson D J, Lan H Y, Hill P A, Atkins R C
Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.
Kidney Int Suppl. 1994 Feb;45:S79-82.
There is good evidence from experimental studies that glomerular macrophages are important in acute renal injury and an increasing acceptance that they also play a role in chronic glomerular injury by stimulating mesangial cell proliferation and glomerulosclerosis. However, it is now evident that the contribution of macrophages and T cells within the interstitium must be taken into account. Indeed, if it is proved that progressive renal injury occurs via interstitial DTH mechanisms, regardless of the nature of the initial glomerular insult, then such mechanisms may provide a suitable target for the development of novel therapeutic strategies.
实验研究有充分证据表明，肾小球巨噬细胞在急性肾损伤中起重要作用，并且越来越多的人认为它们通过刺激系膜细胞增殖和肾小球硬化在慢性肾小球损伤中也发挥作用。然而，现在很明显，必须考虑间质内巨噬细胞和T细胞的作用。事实上，如果证明渐进性肾损伤是通过间质迟发型超敏反应机制发生的，而不管最初肾小球损伤的性质如何，那么这些机制可能为开发新的治疗策略提供合适的靶点。
