Fok M V, Zaritskiĭ A R, Prokopenko G A, Lobchenko I M
Zh Obshch Biol. 1994 Jan-Feb;55(1):84-95.
A method for calculation of oxygen metabolism kinetics in vivo for different blood pH and for different inhaled air pressure is proposed. It is based on joint solution of equations of oxygen balance in lungs and in capillaries of oxygen-consuming tissues. All calculations were carried out within the physiological range of the above parameters. The value of maximum physical load was estimated for each set of the parameters. This load was evaluated in respect to the maximal oxygen consumption possible under conditions selected. Only data borrowed from normal physiology were used in calculations. It was shown that oxyhemoglobin dissociation curve shifts (for example, caused by blood pH deviation from its norm) does not have substantial influence on the organism ability to produce work, on its supplement with the oxygen, and can not cause pathologies at acidosis and alkalosis. This new result was obtained due to adoption of strict equality of the oxygen flows absorbed by blood in the lungs and of the oxygen given back by the blood in capillaries of the oxygen-consuming tissues.
提出了一种计算不同血液pH值和不同吸入气压下体内氧代谢动力学的方法。它基于肺和耗氧组织毛细血管中氧平衡方程的联合求解。所有计算均在上述参数的生理范围内进行。针对每组参数估计了最大体力负荷值。该负荷是根据所选条件下可能的最大耗氧量来评估的。计算中仅使用了来自正常生理学的数据。结果表明，氧合血红蛋白解离曲线的移动（例如，由血液pH值偏离正常引起）对机体做功能力、氧供应没有实质性影响，并且在酸中毒和碱中毒时不会引发病变。这一新结果是由于采用了肺中血液吸收的氧流量与耗氧组织毛细血管中血液释放的氧流量严格相等的条件而获得的。
