Irwin D E, Savitz D A, St André K A, Hertz-Picciotto I
Department of Epidemiology, School of Public Health, University of North Carolina-Chapel Hill.
Am J Ind Med. 1994 Mar;25(3):349-59. doi: 10.1002/ajim.4700250305.
The relationship between occupational exposures and the risk of pregnancy-induced hypertension (PIH) was investigated in a cohort of 5,605 enlisted active duty military women who gave birth during a 2-year period of time. A panel of experts, unaware of disease status, classified the women's job titles as "high," "medium," or "low" for a variety of occupational exposures. PIH was identified through hospital discharge ICD-9 diagnosis codes. Nulliparas were found to have a significantly increased risk ratio (RR) for PIH (RR = 2.3) compared with parous women. Nulliparas employed in jobs involving high levels of physical activity were at significantly decreased risk of PIH compared to nulliparas working at low levels of physical activity (construction craftsmen, RR = 0.37; unskilled laborers RR = 0.71). Occupational exposure to hazardous chemicals was not related to risk of PIH. Although the study results are limited by aggregate exposure classification, they suggest no adverse influence of occupational exertion and a possible beneficial role among nulliparas.
在一个为期两年的时间段内分娩的5605名现役女兵队列中，研究了职业暴露与妊娠高血压（PIH）风险之间的关系。一个对疾病状态不知情的专家小组，根据各种职业暴露情况，将这些女性的工作头衔分为“高”“中”或“低”。通过医院出院ICD - 9诊断编码来确定PIH。与经产妇相比，初产妇患PIH的风险比（RR）显著增加（RR = 2.3）。与从事低体力活动工作的初产妇相比，从事高强度体力活动工作的初产妇患PIH的风险显著降低（建筑工匠，RR = 0.37；非技术工人RR = 0.71）。职业接触有害化学物质与PIH风险无关。尽管研究结果受到总体暴露分类的限制，但它们表明职业劳累没有不良影响，并且在初产妇中可能起到有益作用。
