Makarovskaia L N, Tinker L A, Markovskaia E I, Zurabian V A, Ryzhkova V V
Antibiot Khimioter. 1996;41(11):25-7.
It was shown that the use of ampicillin, azlocillin or polymyxin 24 or 96 hours after the plague infection at the background of the every-day use of rifampicin in the doses protecting only 30 per cent of the animals from death provided 80-100-percent survival of the animals. With the every-day use of ampicillin, azlocillin or polymyxin in succession with rifampicin there was observed a 3-fold increases in the survival of the albino mice as compared to those exposed to an analogous dose of rifampicin alone. A decrease in the number of administrations of the above drugs and an increase in the intervals between the administration also resulted in a significant rise of the animal survival in comparison with that after the every-day use of a similar dose of rifampicin.
结果表明，在每天使用仅能保护30%的动物免于死亡剂量的利福平的基础上，在鼠疫感染后24或96小时使用氨苄西林、阿洛西林或多粘菌素，可使动物存活率达到80%-100%。与仅接受类似剂量利福平的动物相比，每天依次使用氨苄西林、阿洛西林或多粘菌素和利福平，可使白化小鼠的存活率提高3倍。与每天使用类似剂量利福平相比，减少上述药物的给药次数并增加给药间隔时间，也可显著提高动物存活率。
