Jeannet M, Speck B, Rubinstein A, Pelet B, Wyss M, Kummer H
Acta Haematol. 1976;55(3):129-39. doi: 10.1159/000208005.
Three consecutive patients considered to have end-stage acquired aplastic anaemia were given 100-160 mg/kg antilymphocyte globulin (ALG) i.v. followed by an infusion of 2-3.8 x 10(8) nucleated marrow cells/kg i.v. from HL-A one haplotype-identical, MLC-positive family donors. All patients showed autologous marrow reconstitutions lasting now 2-3 1/2 years. No clear-cut evidence of marrow engraftment could be established and no graft-versus-host disease was seen. It is assumed that these patients had some normal pluripotent haemopoetic stem cells which proved to be able of endoreduplication and of going into cycle after ALG conditioning and allogeneic marrow transfusion.
连续三位被认为患有终末期获得性再生障碍性贫血的患者接受了静脉注射100 - 160毫克/千克抗淋巴细胞球蛋白（ALG），随后静脉输注来自单倍型相同、混合淋巴细胞培养阳性的家族供体的2 - 3.8×10⁸有核骨髓细胞/千克。所有患者均出现了持续2至3年半的自体骨髓重建。未明确证实有骨髓植入，也未见移植物抗宿主病。据推测，这些患者有一些正常的多能造血干细胞，在接受ALG预处理和异基因骨髓输注后，这些干细胞能够进行核内复制并进入细胞周期。
