大剂量静脉注射环磷酰胺逆转系统性红斑狼疮继发的再生障碍性贫血
Reversal of aplastic anaemia secondary to systemic lupus erythematosus by high-dose intravenous cyclophosphamide.
作者信息
Walport M J, Hubbard W N, Hughes G R
出版信息
Br Med J (Clin Res Ed). 1982 Sep 18;285(6344):769-70. doi: 10.1136/bmj.285.6344.769.
Abstract
Aplastic anaemia is rare as a primary feature of systemic lupus erythematosus and is more commonly a complication of treatment with cytotoxic drugs. Three years after starting treatment for systemic lupus erythematosus a 22-year-old woman developed bone-marrow depression. Azathioprine was thought to be responsible and was withdrawn. The aplastic anaemia worsened despite treatment with prednisolone. In view of clinical and serological evidence of lupus disease activity the patient was given high-dose intravenous cyclophosphamide and the aplastic anaemia responded in a sustained manner.In such cases of continued disease activity high-dose immunosuppressive agents may prove effective.
摘要
再生障碍性贫血作为系统性红斑狼疮的主要特征较为罕见，更常见的是细胞毒性药物治疗的并发症。一名22岁女性在开始系统性红斑狼疮治疗三年后出现骨髓抑制。认为是硫唑嘌呤所致，遂停用。尽管使用泼尼松龙治疗，再生障碍性贫血仍恶化。鉴于狼疮疾病活动的临床和血清学证据，给予患者大剂量静脉注射环磷酰胺，再生障碍性贫血得到持续缓解。在这种疾病持续活动的情况下，大剂量免疫抑制剂可能证明有效。
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