Benahmed M, Blottiere H, Praloran V, Daculsi G
Laboratoire de Recherche sur les Matériaux d'Intérêt Biologique CNRS, Faculté de Chirurgie Dentaire, Nantes University, France.
Biomaterials. 1994 Jan;15(1):25-30. doi: 10.1016/0142-9612(94)90191-0.
The monocyte is an essential element in cellular immunity. Consequently, its role in the biocompatibility process is important. A model study of the degradation of bioactive ceramics (calcium phosphate) using human peripheral blood monocytes activated by 1,25 (OH)2 VD3 and interferon (IFN)-gamma was implemented. Activated monocytes cultivated on calcium phosphate tablets led to cellular morphological modifications and to changes in the number of nuclei (from d 2 to 14). IFN-gamma promoted adhesion, the appearance of cytoplasmic extensions and multinuclei. Cavity resorption activity on the material was observed simultaneously.
单核细胞是细胞免疫中的重要组成部分。因此，其在生物相容性过程中的作用至关重要。开展了一项模型研究，利用经1,25(OH)2 VD3和干扰素(IFN)-γ激活的人外周血单核细胞，研究生物活性陶瓷（磷酸钙）的降解情况。在磷酸钙片上培养的活化单核细胞导致细胞形态改变以及细胞核数量变化（从第2天到第14天）。IFN-γ促进了细胞黏附、细胞质突起和多核的出现。同时观察到材料上的腔隙吸收活性。
