Witteman E M, Mravunac M, Becx M J, Hopman W P, Verschoor J S, Tytgat G N, de Koning R W
Department of Gastroenterology and Hepatology, Nijmegen University Hospital, The Netherlands.
J Clin Pathol. 1995 Mar;48(3):250-6. doi: 10.1136/jcp.48.3.250.
To investigate the effect of eradication of Helicobacter pylori infection on gastric epithelial damage and gastritis, scored according to the Sydney system.
Gastritis scores and epithelial damage were assessed in gastric biopsy specimens before, and five weeks and one year after anti-H pylori therapy in 66 patients with H pylori related gastritis.
The mean initial levels of activity, inflammation, atrophy, intestinal metaplasia, and H pylori scores were higher in the antrum than in the corpus or fundus. Eradication of H pylori resulted in an improvement in the mean inflammatory score in antral biopsy specimens from 2.23 before treatment to 1.32 and 1.06, respectively, five weeks and one year after treatment. Corresponding values for fundic biopsy specimens were 1.30, 0.36 and 0.35. Activity scores improved from 1.41 before treatment to 0.13 and zero, respectively, five weeks and one year after treatment in antral biopsy specimens and from 0.60 before treatment to zero in fundic biopsy specimens. Before treatment, epithelial damage was present in 51% of biopsy specimens taken from the antrum and 23% of those from the corpus. Five weeks after eradication of H pylori none of the biopsy specimens revealed evidence of epithelial damage.
Eradication of H pylori is followed by a rapid, significant improvement in the gastritis score and resolution of epithelial damage in antral and fundic mucosa.
根据悉尼系统评分，研究根除幽门螺杆菌感染对胃上皮损伤和胃炎的影响。
对66例幽门螺杆菌相关性胃炎患者在抗幽门螺杆菌治疗前、治疗后5周和1年时的胃活检标本进行胃炎评分和上皮损伤评估。
胃窦部活动度、炎症、萎缩、肠化生及幽门螺杆菌评分的平均初始水平高于胃体或胃底。根除幽门螺杆菌后，胃窦活检标本的平均炎症评分从治疗前的2.23分别改善至治疗后5周的1.32和1年后的1.06。胃底活检标本的相应值分别为1.30、0.36和0.35。胃窦活检标本的活动度评分从治疗前的1.41分别改善至治疗后5周的0.13和1年后的0，胃底活检标本从治疗前的0.60改善至0。治疗前，51%的胃窦活检标本和23%的胃体活检标本存在上皮损伤。根除幽门螺杆菌5周后，所有活检标本均未显示上皮损伤迹象。
根除幽门螺杆菌后，胃窦和胃底黏膜的胃炎评分迅速显著改善，上皮损伤得以消退。
