Sillanpää M, Donner M
Acta Paediatr Scand. 1976 Mar;65(2):209-15. doi: 10.1111/j.1651-2227.1976.tb16540.x.
The antiepileptic efficiency of dipropylacetate (DPA) was studied in 80 epileptic children who suffered either from seizures resistant to previous medication, so-called idiopathic epilepsy or progressive myoclonus epilepsy. The average peroral daily dosage of DPA was 21 mg/kg divided into 2 to 3 doses. DPA was most effective in cases with 1) so-called idiopathic epilepsy (genuine petit mal, photogenic epilepsy, myoclonic petit mal in older children), 2) seizures beginning in later childhood years, 3) photosensitive and hyperventilation-sensitive seizures, 4) EEG showing symmetric generalized spike-slow wave complexes provoked by photostimulation, 5) EEG without generalized disturbance or focal findings, 6) normal neurological and mental status, 7) progressive myoclonus epilepsy. DPA may thus be recommended for the treatment of the above-mentioned cases and, due to good treatment results, also tried in other types of epilepsy.
对80名癫痫患儿进行了丙戊酸二丙酯（DPA）抗癫痫疗效的研究，这些患儿患有对先前药物治疗耐药的癫痫发作，即所谓的特发性癫痫或进行性肌阵挛癫痫。DPA的平均口服日剂量为21mg/kg，分2至3次服用。DPA在以下情况最为有效：1）所谓的特发性癫痫（典型失神发作、光敏感性癫痫、大龄儿童肌阵挛性失神发作）；2）在儿童后期开始发作的癫痫；3）光敏感性和过度换气敏感性癫痫发作；4）脑电图显示光刺激诱发对称的全身性棘慢复合波；5）脑电图无全身性紊乱或局灶性表现；6）神经和精神状态正常；7）进行性肌阵挛癫痫。因此，DPA可推荐用于上述病例的治疗，并且由于治疗效果良好，也可尝试用于其他类型的癫痫。
