Cavdar Ercüment, Ozkaya Abdullah, Alper Burcu
Kemalpaşa State Hospital, Clinic of Ophthalmology, 35730 Izmir, Turkey.
J Ophthalmol. 2013;2013:908017. doi: 10.1155/2013/908017. Epub 2013 May 7.
Purpose. To evaluate the changes of flash electroretinography (fERG) and pattern visual evoked potentials (pVEP) in ocular hypertension (OHT) patients. Methods. Twenty-five OHT patients and 30 healthy volunteers were enrolled for this cross-sectional study. Opthalmologic examinations, visual field tests, pVEP and fERG were performed. The main outcome measures were the differences between pVEP and fERG parameters. Results. The mean age of OHT patients and volunteers were 57 ± 12.25 years (range 30-65 years), and 53.25 ± 12.0 years (range 30-65 years), respectively. The mean amplitude of the pVEP was statistically lower in the OHT group (P < 0.05). Latency of the two groups was different; however, the difference was not statistically significant (P > 0.05). In fERG of OHT group, there was a significant decrease in the amplitude of the oscillatory potentials (Ops), and a significant delay in latency of rod and cone waves (all P < 0.05). There was no significant change in the flicker fERG waves between the two groups (P > 0.05). Conclusions. Although we found a decrease in Ops amplitude and a prolonged latency in flicker fERG, only the decrease in Ops amplitude was statistically significant between the two groups. The amplitude of Ops wave and amplitude of pVEP may reflect early glaucomatous damage in OHT patients.
目的。评估高眼压症（OHT）患者闪光视网膜电图（fERG）和图形视觉诱发电位（pVEP）的变化。方法。本横断面研究纳入了25例高眼压症患者和30名健康志愿者。进行了眼科检查、视野测试、pVEP和fERG检查。主要观察指标为pVEP和fERG参数之间的差异。结果。高眼压症患者和志愿者的平均年龄分别为57±12.25岁（范围30 - 65岁）和53.25±12.0岁（范围30 - 65岁）。高眼压症组pVEP的平均波幅在统计学上较低（P < 0.05）。两组的潜伏期不同；然而，差异无统计学意义（P > 0.05）。在高眼压症组的fERG中，振荡电位（Ops）的波幅显著降低，视杆和视锥细胞波的潜伏期显著延迟（均P < 0.05）。两组之间闪烁fERG波无显著变化（P > 0.05）。结论。尽管我们发现Ops波幅降低和闪烁fERG潜伏期延长，但两组之间仅Ops波幅降低具有统计学意义。Ops波幅和pVEP波幅可能反映高眼压症患者早期青光眼性损害。
