肌苷片用于儿童癌症患者局部带状疱疹：初步对照研究。
Inosiplex for localized herpes zoster in childhood cancer patients: preliminary controlled study.
作者信息
Feldman S, Hayes F A, Chaudhary S, Ossi M
出版信息
Antimicrob Agents Chemother. 1978 Sep;14(3):495-7. doi: 10.1128/AAC.14.3.495.
Abstract
By multiple criteria, inosiplex-a reputed stimulator of virus-sensitized lymphocytes-had no demonstrable therapeutic effects in a preliminary controlled study of patients with localized herpes zoster and cancer. Lymphocytes from the six drug-treated patients were no more responsive to varicella-zoster antigen and phytohemagglutinin than were lymphocytes from seven patients who received a placebo.
摘要
根据多项标准，在一项针对局部带状疱疹和癌症患者的初步对照研究中，作为一种著名的病毒致敏淋巴细胞刺激剂，肌苷聚胺没有明显的治疗效果。与7名接受安慰剂治疗的患者的淋巴细胞相比，6名接受药物治疗患者的淋巴细胞对水痘-带状疱疹抗原和植物血凝素的反应并没有更强。
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Inosiplex for localized herpes zoster in childhood cancer patients: preliminary controlled study.肌苷片用于儿童癌症患者局部带状疱疹：初步对照研究。
Antimicrob Agents Chemother. 1978 Sep;14(3):495-7. doi: 10.1128/AAC.14.3.495.
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Inosiplex in recurrent herpes simplex infection.肌苷在复发性单纯疱疹感染中的应用。
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引用本文的文献
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Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases.肌苷普乐安：对抗多种病毒感染和非传染性疾病的关键药物。
Adv Ther. 2019 Aug;36(8):1878-1905. doi: 10.1007/s12325-019-00995-6. Epub 2019 Jun 5.
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Ribavirin and inosiplex: a review of their present status in viral diseases.利巴韦林与肌苷：它们在病毒性疾病中的现状综述
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Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.异丙肌苷。对其药效学、药代动力学特性及治疗效果的初步综述。
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本文引用的文献
1
Cellular immunity in host resistance to viral infections.宿主对病毒感染的细胞免疫。
Arch Intern Med. 1970 Jul;126(1):125-34.
2
Effect of isoprinosine against challenge with A(H3N2)-Hong Kong influenza virus in volunteers.异丙肌苷对志愿者感染A(H3N2) - 香港流感病毒的挑战的影响。
Antimicrob Agents Chemother. 1973 Apr;3(4):506-9. doi: 10.1128/AAC.3.4.506.
3
Viral infection and immunity.病毒感染与免疫
Med Clin North Am. 1972 Mar;56(2):353-70. doi: 10.1016/s0025-7125(16)32401-4.
4
Anti-herpesvirus action of isoprinosine.异丙肌苷的抗疱疹病毒作用。
Antimicrob Agents Chemother. 1974 Feb;5(2):153-60. doi: 10.1128/AAC.5.2.153.
5
Mechanisms of recovery from a generalized viral infection: mousepox. 3. Regression infectious foci.全身性病毒感染（鼠痘）的恢复机制。3. 感染灶的消退
J Exp Med. 1971 May 1;133(5):1090-104. doi: 10.1084/jem.133.5.1090.
6
Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells.从全身性病毒感染中恢复的机制：鼠痘。II. 免疫淋巴细胞介导的恢复机制的被动转移
J Exp Med. 1971 May 1;133(5):1074-89. doi: 10.1084/jem.133.5.1074.
7
Mechanisms of recovery from a generalized viral infection: mousepox. I. The effects of anti-thymocyte serum.从全身性病毒感染中恢复的机制：鼠痘。I. 抗胸腺细胞血清的作用
J Exp Med. 1970 Nov;132(5):1035-54. doi: 10.1084/jem.132.5.1035.
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Evaluation of topical polyinosinic acid-polycytidylic acid in treatment of localized herpes zoster in children with cancer: a randomized, double-blind controlled study.局部应用聚肌苷酸-聚胞苷酸治疗癌症患儿局部带状疱疹的评估：一项随机、双盲对照研究。
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A viremic phase for herpes zoster in children with cancer.癌症患儿带状疱疹的病毒血症期。
J Pediatr. 1977 Oct;91(4):597-600. doi: 10.1016/s0022-3476(77)80509-x.
10
In vitro studies on cell-mediated immunity in patients treated with inosiplex for herpes virus infection.对接受肌苷片治疗疱疹病毒感染患者的细胞介导免疫的体外研究。
Ann N Y Acad Sci. 1977 Mar 4;284:190-6. doi: 10.1111/j.1749-6632.1977.tb21950.x.
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