Barragán J M, Rodríguez R E, Blázquez E
Department of Biochemistry and Molecular Biology, University of Salamanca, Spain.
Am J Physiol. 1994 Mar;266(3 Pt 1):E459-66. doi: 10.1152/ajpendo.1994.266.3.E459.
This study was designed to determine the effects of glucagon-like peptides (GLP) on arterial blood pressure and heart rate. Although glucagon caused a minimal effect and GLP-1-(1-37) produced a moderate increase of both systolic and diastolic blood pressure, GLP-1-(7-36) amide induced the greatest increases in both parameters. Systolic and diastolic blood pressure and heart rate values increased when doses of the peptides were increased. By contrast, GLP-2 did not modify either arterial blood pressure or heart rate values. To determine whether the effects of GLP-1-(7-36) amide were mediated through catecholamines, the rats were pretreated with reserpine, propranolol, or phentolamine before administration of the peptide. In these three experimental groups, GLP-1-(7-36) amide increases mean arterial blood pressure and heart rate to the same level or even greater than that observed in nonpretreated rats. These findings indicate that GLP-1-(7-36) amide significantly increases arterial blood pressure and heart rate and that these effects are not mediated through catecholamines.
本研究旨在确定胰高血糖素样肽（GLP）对动脉血压和心率的影响。尽管胰高血糖素的作用极小，GLP-1-(1-37)使收缩压和舒张压均有适度升高，但GLP-1-(7-36)酰胺引起这两个参数的升高幅度最大。当肽的剂量增加时，收缩压、舒张压和心率值均升高。相比之下，GLP-2对动脉血压或心率值均无影响。为了确定GLP-1-(7-36)酰胺的作用是否通过儿茶酚胺介导，在给予该肽之前，先用利血平、普萘洛尔或酚妥拉明对大鼠进行预处理。在这三个实验组中，GLP-1-(7-36)酰胺使平均动脉血压和心率升高到与未预处理大鼠相同的水平，甚至更高。这些发现表明，GLP-1-(7-36)酰胺可显著升高动脉血压和心率，且这些作用并非通过儿茶酚胺介导。
