Schroer T A
Department of Biology, Johns Hopkins University, Baltimore, MD 21218.
Curr Opin Cell Biol. 1994 Feb;6(1):69-73. doi: 10.1016/0955-0674(94)90118-x.
Molecular cloning studies have provided valuable structural information about the different subunits of cytoplasmic dynein and their relationships to their axonemal dynein counterparts. Recent unexpected findings regarding the role of this enzyme in mitosis have emerged from mutational analyses and microinjection experiments, while studies of organelle transport in vivo have revealed clues to mechanisms for physiological regulation of dynein activity.
分子克隆研究提供了关于胞质动力蛋白不同亚基的有价值的结构信息，以及它们与轴丝动力蛋白对应亚基的关系。关于这种酶在有丝分裂中作用的最新意外发现来自突变分析和显微注射实验，而体内细胞器运输的研究揭示了动力蛋白活性生理调节机制的线索。
