Bodine-Fowler S
Department of Orthopaedic Surgery, University of California, San Diego 92161.
J Voice. 1994 Mar;8(1):53-62. doi: 10.1016/s0892-1997(05)80319-4.
Skeletal muscle has a remarkable capacity for regeneration after injuries resulting in either partial or complete damage to the muscle fibers. Muscle damage occurs following a variety of injuries including direct injury caused by crushing, puncturing, cutting, or freezing; ischemia; direct application of local anesthetics; eccentric exercise, and a variety of neuromuscular diseases. Regardless of the injury, regeneration usually follows a characteristic sequence and is limited by three major factors that will be discussed in this overview of the processes involved in degeneration and regeneration of muscle. The major factors limiting the ability of skeletal muscle to regenerate after trauma or disease are a viable population of satellite cells, reinnervation, and revascularization.
骨骼肌在遭受导致肌纤维部分或完全损伤的损伤后，具有显著的再生能力。肌肉损伤可发生在多种损伤之后，包括挤压、穿刺、切割或冷冻造成的直接损伤；局部缺血；局部麻醉剂的直接应用；离心运动以及各种神经肌肉疾病。无论损伤情况如何，再生通常遵循特定的顺序，并且受到三个主要因素的限制，这三个因素将在本次关于肌肉退化和再生过程的概述中进行讨论。限制骨骼肌在创伤或疾病后再生能力的主要因素是卫星细胞的存活群体、神经再支配和血管再生。
