Kay R M, Kabo J M, Seeger L L, Eckardt J J
Department of Orthopaedic Surgery, UCLA School of Medicine 90024.
Clin Orthop Relat Res. 1994 May(302):92-100.
A custom-designed, hydroxyapatite-coated distal femoral replacement was developed and implanted in five individuals at the authors' hospital. The indications for this type of prosthesis were a multiply failed cemented endoprosthesis in two individuals; a revision of an infected, previously cemented endoprosthesis in another; a primary low-grade sarcoma in a fourth, and a stage III giant cell tumor in the final individual. Mean follow-up time was 3.3 years (range, 2.9-3.5 years). The functional results, based on the Musculoskeletal Tumor Society (MSTS) criteria, were excellent in one patient (20%) and good in four patients (80%). Musculoskeletal Tumor Society functional scores ranged from 25 to 35 (mean, 29.8). No patient had thigh pain. All the femoral components appeared well fixed on radiographic evaluation. These preliminary results indicate that a hydroxyapatite-coated distal femoral replacement may represent a viable alternative to a cemented endoprosthesis for aggressive benign lesions and low-grade sarcomas requiring resection. In addition, it appears to be a viable solution for failed cemented endoprostheses in individuals who have survived their disease.
作者所在医院研发了一种定制设计的、涂有羟基磷灰石的股骨远端置换物,并将其植入了5名患者体内。植入这类假体的指征包括:两名患者的骨水泥型内置假体多次失败;另一名患者为感染性骨水泥型内置假体的翻修;第四名患者为原发性低度肉瘤;最后一名患者为III期骨巨细胞瘤。平均随访时间为3.3年(范围为2.9 - 3.5年)。根据肌肉骨骼肿瘤学会(MSTS)标准,功能结果为1例患者(20%)优秀,4例患者(80%)良好。肌肉骨骼肿瘤学会功能评分范围为25至35(平均为29.8)。没有患者出现大腿疼痛。影像学评估显示所有股骨组件固定良好。这些初步结果表明,对于需要切除的侵袭性良性病变和低度肉瘤,涂有羟基磷灰石的股骨远端置换物可能是骨水泥型内置假体的一种可行替代方案。此外,对于在疾病中存活下来的个体,它似乎也是骨水泥型内置假体失败后的一种可行解决方案。