Vernon S D, Reeves W C, Clancy K A, Laga M, St Louis M, Gary H E, Ryder R W, Manoka A T, Icenogle J P
Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
J Infect Dis. 1994 May;169(5):1108-12. doi: 10.1093/infdis/169.5.1108.
Cericovaginal lavage samples from 124 human immunodeficiency virus type 1 (HIV-1)-seropositive and 126 HIV-1-seronegative women were collected monthly for 8 months and tested for human papillomavirus (HPV) DNA. The estimated prevalence of HPV was 42.8% in HIV-1-seropositive and 13.4% in -seronegative women (P < .001). There was no significant difference in HPV DNA detection in HIV-1-seropositive women with CD4 cell counts of < 300/mm3 (50% HPV-positive), 300-499/mm3 (36.4% HPV-positive), or > or = to 500/mm3 (40.5% HIV-positive). However, HIV-1-seropositive women who were more immunocompromised, as indicated by lower CD4 cell counts, were more likely to shed HPV persistently. The quantity of HPV DNA detected in cervicovaginal lavage samples was similar in HIV-1-seropositive and -seronegative women. This study further defined the characteristics of HPV infections in HIV-1-infected women.
每月收集124名1型人类免疫缺陷病毒（HIV-1）血清阳性和126名HIV-1血清阴性女性的宫颈阴道灌洗样本，持续8个月，并检测人乳头瘤病毒（HPV）DNA。HIV-1血清阳性女性中HPV的估计患病率为42.8%，血清阴性女性中为13.4%（P<0.001）。CD4细胞计数<300/mm3的HIV-1血清阳性女性（HPV阳性率50%）、300-499/mm3的女性（HPV阳性率36.4%）或≥500/mm3的女性（HPV阳性率40.5%）的HPV DNA检测无显著差异。然而，CD4细胞计数较低表明免疫功能更低下的HIV-1血清阳性女性更有可能持续排出HPV。HIV-1血清阳性和血清阴性女性的宫颈阴道灌洗样本中检测到的HPV DNA数量相似。本研究进一步明确了HIV-1感染女性HPV感染的特征。
