Hillemanns P, Ellerbrock T V, McPhillips S, Dole P, Alperstein S, Johnson D, Sun X W, Chiasson M A, Wright T C
Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
AIDS. 1996 Dec;10(14):1641-7. doi: 10.1097/00002030-199612000-00008.
To determine the prevalence of anal human papillomavirus (HPV) infections and anal cytologic abnormalities in HIV-seropositive and HIV-seronegative women.
This cross-sectional study of a cohort of women with known HIV serostatus involved a standardized interview and a gynecologic examination, including a cytologic evaluation of the cervix and anus. Anal swabs were tested for HPV DNA using the Hybrid Capture assay.
Two HIV/AIDS clinics, a sexually transmitted disease clinic, a methadone clinic and women enrolled in a study of HIV heterosexual transmission in the greater New York City metropolitan area.
One hundred and two HIV-seropositive and 96 HIV-seronegative women were selected from an ongoing study of the gynecologic manifestations of HIV infection.
Detection of anal HPV DNA and anal cytologic abnormalities.
Anal cytologic abnormalities were detected in 27 (26%) of the 102 HIV-seropositive women and in six (7%) of 96 HIV-seronegative women. Five (5%) of the anal smears from the HIV-seropositive women and one (1%) from the HIV-seronegative women had low-grade anal intra-epithelial neoplasia. The remainder of the anal cytologic abnormalities were classified as mild squamous cytologic atypia. HPV DNA was detected in 30 (29%) of 102 HIV-seropositive and two (2%) of 96 HIV-seronegative women. Of the 33 patients with anal cytologic abnormalities, 19 (58%) had anal HPV DNA detected as compared to 13 (8%) of 160 women without cytologic abnormalities (P < 0.001). In a multivariate logistic regression analysis, HIV-seropositivity was found to be an independent risk factor for both anal HPV infection and anal cytologic abnormalities and the strength of the association was greater in women with lower CD4+ T-lymphocyte counts.
The prevalence of both anal cytologic abnormalities and anal HPV infection are significantly increased in HIV-seropositive women.
确定HIV血清阳性和HIV血清阴性女性肛门人乳头瘤病毒（HPV）感染及肛门细胞学异常的患病率。
这项针对已知HIV血清状态女性队列的横断面研究包括标准化访谈和妇科检查，其中有宫颈和肛门的细胞学评估。采用杂交捕获法检测肛门拭子中的HPV DNA。
两家HIV/艾滋病诊所、一家性传播疾病诊所、一家美沙酮诊所，以及大纽约市都会区参加HIV异性传播研究的女性。
从一项正在进行的HIV感染妇科表现研究中选取102名HIV血清阳性女性和96名HIV血清阴性女性。
检测肛门HPV DNA和肛门细胞学异常。
102名HIV血清阳性女性中有27名（26%）检测出肛门细胞学异常，96名HIV血清阴性女性中有6名（7%）检测出异常。HIV血清阳性女性的肛门涂片中有5名（5%）出现低度肛门上皮内瘤变，HIV血清阴性女性中有1名（1%）出现该病变。其余肛门细胞学异常被归类为轻度鳞状细胞异型性。102名HIV血清阳性女性中有30名（29%）检测出HPV DNA，96名HIV血清阴性女性中有2名（2%）检测出。在33名有肛门细胞学异常的患者中，19名（58%）检测出肛门HPV DNA，而160名无细胞学异常的女性中有13名（8%）检测出（P<0.001）。在多因素逻辑回归分析中，发现HIV血清阳性是肛门HPV感染和肛门细胞学异常的独立危险因素，且在CD4+T淋巴细胞计数较低的女性中这种关联更强。
HIV血清阳性女性的肛门细胞学异常和肛门HPV感染患病率均显著增加。
