Lewis M J, June H L
Howard University.
J Exp Anal Behav. 1994 Mar;61(2):223-9. doi: 10.1901/jeab.1994.61-223.
The effects of two widely abused drugs, ethanol and cocaine, were examined alone and in combination on intracranial reward processes. In agreement with previous research, higher doses of both cocaine and ethanol alone produced facilitation of behavior maintained by brain stimulation reward. Low intraperitoneal doses of ethanol and cocaine, which alone did not affect performance, were found to reduce stimulation reward threshold and modestly increase response rate. The enhancement of brain stimulation reward by the combination of ethanol and cocaine suggests that both drugs may produce their rewarding effects through common neuronal substrates and that they may potentiate the abuse of each other.
研究了两种广泛滥用的药物——乙醇和可卡因，单独使用以及联合使用时对颅内奖赏过程的影响。与先前的研究一致，单独使用较高剂量的可卡因和乙醇都会促进由脑刺激奖赏维持的行为。腹腔注射低剂量的乙醇和可卡因，单独使用时不影响行为表现，但发现会降低刺激奖赏阈值并适度提高反应率。乙醇和可卡因联合使用增强脑刺激奖赏，这表明两种药物可能通过共同的神经元底物产生奖赏效应，并且它们可能会相互增强成瘾性。
