Mora F, Rolls E T, Burton M J, Shaw G S, Shaw G S
Pharmacol Biochem Behav. 1976 Feb;4(2):211-6. doi: 10.1016/0091-3057(76)90018-6.
In a dose-response experiment it was shown that intraperitoneal injections of 0.062 mg/kg, and 0.1 mg/kg of the dopamine-receptor blocking agent and neuroleptic spiroperidol severely attenuate self-stimulation in the orbitofrontal cortex, hypothalamus, and in the region of the locus coeruleus, in the rhesus monkey and in the squirrel monkey. In the rhesus monkey intracranial injections of 6 mug of spiroperidol bilaterally into the nucleus accumbens or the hypothalamus attenuated self-stimulation of the amygdala, and injections into the orbitofrontal cortex attenuated self-stimulation of the amygdala and lateral hypothalamus. Self-stimulation at other sites tested (including the region of the locus coeruleus) was much less affected by the injections, and injections into the region of the locus coeruleus were ineffective. These results together with other control experiments suggest that spiroperidol can attenuate self-stimulation in the monkey independently of any motor impairment or sedation produced, and that dopamine receptors in particular brain regions are involved in self-stimulation of particular brain sites.
在一项剂量反应实验中发现，给恒河猴和松鼠猴腹腔注射0.062毫克/千克及0.1毫克/千克的多巴胺受体阻断剂及抗精神病药物螺哌啶醇，会严重减弱其在眶额叶皮质、下丘脑以及蓝斑区域的自我刺激行为。在恒河猴中，向伏隔核或下丘脑双侧颅内注射6微克螺哌啶醇会减弱杏仁核的自我刺激行为，而向眶额叶皮质注射则会减弱杏仁核和下丘脑外侧的自我刺激行为。对其他测试部位（包括蓝斑区域）的自我刺激行为，注射药物的影响要小得多，而向蓝斑区域注射则无效。这些结果连同其他对照实验表明，螺哌啶醇可独立于所产生的任何运动障碍或镇静作用而减弱猴子的自我刺激行为，且特定脑区的多巴胺受体参与了特定脑区部位的自我刺激行为。
