Baird A
Department of Molecular and Cellular Growth Biology, Whittier Institute for Diabetes and Endocrinology, La Jolla, California 92037.
Curr Opin Neurobiol. 1994 Feb;4(1):78-86. doi: 10.1016/0959-4388(94)90035-3.
Although first characterized by virtue of their ability to stimulate endothelial cell proliferation in vitro and angiogenesis in vivo, the fibroblast growth factors are now also well recognized for their neurotrophic activities. Understanding the physiological significance of these multifunctional, virtually ubiquitous and pluripotential molecules, however, remains enigmatic. Recent advances describing their molecular, biochemical and biological characteristics has led to a better understanding of their role in the central nervous system.
尽管最初是根据其在体外刺激内皮细胞增殖和在体内促进血管生成的能力而被鉴定出来的，但成纤维细胞生长因子如今因其神经营养活性也得到了广泛认可。然而，要理解这些多功能、几乎无处不在且具有多潜能的分子的生理意义，仍然是个谜。描述它们分子、生化和生物学特性的最新进展，使人们对其在中枢神经系统中的作用有了更好的理解。
